Bioactive Small Molecules
Medchemexpress LLC CCC-0975 | 432018-03-6 | 99.5% | 483.89 | 50 MG
This compound is an inhibitor of the hepatitis B virus (HBV), demonstrating an EC50 of 10 μM. It works by interfering with the conversion process of relaxed circular DNA (rcDNA) into covalently closed circular DNA (cccDNA). This action leads to a synchronous reduction in both cccDNA and its precursor, deproteinized rcDNA (DP-rcDNA), without causing their degradation within the cell. This makes it a promising agent for the study of chronic hepatitis B.
Features and Benefits:
- Specifically inhibits hepatitis B virus (HBV) with an EC50 of 10 μM.
- Interferes with the conversion of rcDNA to cccDNA.
- Reduces both cccDNA and DP-rcDNA levels.
- Does not promote intracellular degradation of cccDNA or DP-rcDNA.
- Potentially useful for research into chronic hepatitis B.
Cayman Chemical ANTIBODY namorelIn 50mg
A small molecule agonist of GHS-R1a (Ki = 0.7 nM); induces calcium mobilization in CHO cells expressing rat GHS-R1a in a concentration-dependent manner and GH release from rat pituitary cells (EC50 = 1.5 nM); stimulates GH release in sham and vagotomized rats; increases food intake in rats
Selleck Chemical LLC AZ-33 S0108-25MG
AZ-33 (LDHA Inhibitor 33) is a potent inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 0 5 M LDHA is the key enzyme involved in anaerobic glycolysis which is frequently deregulated in human malignancies
Cayman Chemical ANTIBODY KT195 25mg
A selective inhibitor of ABHD6 (IC50 = 10 nM) with negligible activity against other serine hydrolases such as DAGLβ; used both as a probe to study ABHD6 and as a negative control for studies of DAGLβ
Cayman Chemical NPC-15437hydrochlorIde 5mg
A selective PKC inhibitor (IC50 = 19 µM); inhibits phorbol ester- (Ki = 5 µM) and phosphatidylserine-induced (Ki = 12 µM) PKC activity but does not affect the activity of cAMP-dependent or Ca2+/calmodulin-dependent protein kinases
Cayman Chemical ANTIBODY Propoxur 25mg
A carbamate insecticide; an inhibitor of acetylcholinesterase (IC50 = 4.3 µM); an antagonist of α4β4 subunit-containing nicotinic acetylcholine receptors (IC50 = 165 µM for the rat receptor); lethal to German cockroaches (LD50s = 2.45, 4.73, and 1.06 μg/insect for newly emerged males, newly emerged females, and 4-week-old nymphs, respectively); induces LDH release from and inhibits the growth of flounder gill cells (IC50s = 86.59 and 89.96 μg/ml, respectively); induces yolk sac and pericardial edema in zebrafish embryos at 100 and 200 μg/ml; inhibits rat blood and brain cholinesterase, decreases ambulation and rearing in an open field test, and increases latency to escape foot shock after an audio stimulus in the two-way active avoidance box in rats at 8.3 mg/kg
Medchemexpress LLC 3-(1,2,2-trichlorovinyl)aniline hydrochloride | 81972-27-2 | MFCD09743804 | 98.6% | 259.0 g/mol | C8H7Cl4N | 1 G
3-(1,2,2-trichlorovinyl)aniline hydrochloride is a hydrochloride salt used as a synthetic building block and drug intermediate in medicinal chemistry and organic synthesis. It is intended for research-scale use and supplied in small pack sizes for laboratory synthesis.
- Hydrochloride salt form for improved stability and handling.
- Used as an intermediate in the synthesis of active pharmaceutical compounds.
- High purity (≈98.6%) for reproducible reaction results.
- Suitable for research-scale reactions and small-scale synthesis.
- Well-documented identifiers: CAS 81972-27-2; formula C8H7Cl4N; MW 259.0 g/mol.
Medchemexpress LLC Samidorphan | 852626-89-2 | 99.0% | 370.44 g·mol⁻¹ | C21H26N2O4 | 5MG
Samidorphan is an opioid receptor modulator used in research; it acts as an orally active opioid system modulator with affinity for mu, kappa, and delta opioid receptors. The compound is supplied as a solid (white to yellow), with molecular formula C21H26N2O4 and molecular weight 370.44 g·mol⁻¹, and is intended for preclinical and in vitro studies.
Medchemexpress LLC Adrenocorticotropic Hormone (1-13) | 22006-64-0 | 99.6% | 1623.83 | 5 MG
ACTH (1-13) is a 13-aa peptide with cytoprotective effects in the model of ethanol-induced gastric lesions in rats. It has also shown immunomodulatory effects. Adrenocorticotropic hormone (ACTH) is a tropic hormone produced by the anterior pituitary that regulates cortisol and androgen production and is associated with Addison disease, Cushing syndrome, and Cushing disease.
- Cytoprotective effects in ethanol-induced gastric lesions
- Immunomodulatory effects
- Regulates cortisol and androgen production
- Associated with Addison disease, Cushing syndrome, and Cushing disease
Cayman Chemical ANTIBODY CMPD101 10mg
A GRK2 and GRK3 inhibitor (IC50s = 18 and 5.4 nM, respectively); selective for GRK2 and GRK3 over GRK1, GRK5, GRK6, and GRK7 (IC50s = 3,100, 2,300, >30,000, and 25,000 nM, respectively), as well as ROCK2 and PKCα (IC50s = 1,400 and 8,100 nM, respectively); induces cAMP accumulation in HEK293 cells expressing human β2-adrenergic receptors (EC50 = 10 µM); inhibits electrical field stimulation-, norepinephrine-, phenylephrine-, endothelin-1-, and U-46619-induced contractions in isolated human prostate strips at 50 µM
Cayman Chemical ANTIBODY TrIclosn 100mg
An antibiotic and antifungal; inhibits E. coli FabI and FabIG93V (IC50s = 2 and 10 µM, respectively); active against the bacteria M. epidermidis, M. lysodeikticus, S. aureus, S. lactis, and S. haemolyticus (MICs = 0.03, 0.01, 3, 3, and 1 UG/ml, respectively) and the fungi A. fumigatus, C. albicans, and C. tropicalis (MICs = 10 UG/ml for all); decreases reattachment to dentin chips by, reduces the viability of, and increases LDH secretion from, SG gingival epithelial cells at 30, 100, and 500 µM, respectively
Selleck Chemical LLC Clinical Compound Library L3900-100UL/WELL
A unique collection of 3610 preclinical and clinical compounds for high throughput screening (HTS) and high content screening (HCS)
Cayman Chemical SapacItabIn 5mg
A prodrug form of CNDAC; reduces tumor volume in an MV4-11 mouse xenograft model at 5 and 15 mg/kg alone or in combination with SAHA
Medchemexpress LLC Cyclo(His-Phe) TFA | 147600-13-3 | 99.9% | 398.34 | 5 MG
Cyclo(His-Phe) TFA is a high-purity cyclic dipeptide compound with a molecular weight of 398.34. It is supplied as a white to off-white solid, offering reliable performance for various research and laboratory applications.
- Purity of 99.9%
- Supplied as a white to off-white solid
- For powder, store at -80°C for 2 years or -20°C for 1 year
- For solutions, store at -80°C for 6 months or -20°C for 1 month (sealed storage, away from moisture)
Medchemexpress LLC Fmoc-D-Bip(4,4')-OH | 205526-38-1 | 99.9% | 463.52 | 5 G
Fmoc-D-Bip(4,4')-OH is an alanine derivative. Amino acids and their derivatives are commercially used as ergogenic supplements, influencing anabolic hormone secretion, fuel supply during exercise, mental performance under stress, and preventing exercise-induced muscle damage. They are recognized as beneficial ergogenic dietary substances.
- Alanine derivative
- Used as ergogenic supplements
- Influences secretion of anabolic hormones
- Supplies fuel during exercise
- Improves mental performance during stress
- Prevents exercise-induced muscle damage